Effect of Microcrystalline Cellulose in the Extrusion-Spheronisation Process of Microparticulate-Making Technology: A Systematic Review.


  • Rahmat Santoso Faculty of Pharmacy, Bhakti Kencana University
  • Garnadi Jafar Faculty of Pharmacy, Bhakti Kencana University
  • Evi Ulfah Hayati Faculty of Pharmacy, Bhakti Kencana University


Extrusion/spheronisation, Formulation, MicrocrystallineCellulose, Pellets, Technology.


Multiparticulate consists of several preparations including mini-tablets, powders and pellets. In this review, the aim is to identify the characteristics of microparticulates, especially pellet preparations based on Microcrystalline Cellulose (MCC) using extrusion-spheronisation. Extrusion-spheronisation is the most widely used technique of making pellets involving dry mixing, wet granulation, extrusion, and spheronisation. MCC is the most commonly used additive in the manufacture of pellets in extrusion-spheronisation because it can create pellets with low friability, high porosity, and a smooth surface. However, the shortcoming of MCC-based pellets is the dissolution process is very slow requiring combination with other excipients such as polysorbate 80 and PEG 400. In addition, different treatments on other pellets require the use of different granulation liquids so that they play a role in dissolution. In addition, pellets with a drying process using hot air have smaller sizes compared to those using freeze drying.


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